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Helicobacter pylori infection: association with blood group, demographics and life style in a Pakistani population

Abstract number: P1166

Khuwaja A.K., Wahab F., Valliani A., Ahmed B.

Background: It is well known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. H. pylori infection is one of the most widespread infection in the world. Its intensification in the individual populations is strongly related to economic conditions. Developing countries (Asia, Africa, Central and South America, Eastern Europe) are at high risk, due to people living in poor socioeconomic conditions. This study sought to determine the relationship between H. pylori and ABO blood groups, age, gender, smoking and life style.

Methods: Cross-sectional prospective study was conducted at endoscopy suit in Public Sector Hospitals of Karachi from Sep 2008 to Nov 2008. All the symptomatic patients coming for upper GIT endoscopy were included in this study.

Results: Biopsy for histopathology was taken from 558 patients out of them 222 (39.8%) were males with age range 18–65 years. Age group of 21–40 years was found to be related with H. pylori infection. Out of 558 patients 216 (38.7%) were turned out H. pylori positive with a significant male preponderance (p leqslant R: less-than-or-eq, slant 0.05). Distribution of ABO blood groups in H. Pylori group was A = 66/216 (30.5%), B = 12/216 (5.5%), AB= 6/216 (2.7%) and O = 132/216 (61.1%) which is statistically significant (p leqslant R: less-than-or-eq, slant 0.05). Rh factor was also related to H. pylori infection (p = 0.514). H. pylori could not be related with smoking (p = 0.075). Excessive tea consumption was related to H. pylori infection.

Conclusion: This study demonstrates that H. pylori infection can be related to ABO blood group, age, gender and even lifestyle. People of blood group O are more prone to develop infection related gastritis, ulcers, and even perforations, so they should be cautious against transmission of it. Although there was no correlation found with smoking in this study, other studies have shown otherwise. We suggest that there is a need for making aware people to promote healthy life style, especially after knowing their own health condition and demography.

H. pylori infection association with ABO blood group (n = 558).

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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