HBV-DNA presence in cord blood does not reduce the efficacy of the immunoprophylaxis schedule in neonates of HBeAg-negative chronic HBV-infected women
Abstract number: P1151
Elefsiniotis I., Papadakis M., Vlachos G., Vezali E., Mihas C., Saroglou G., Antsaklis A.
Background/Aim: Intrauterine/transplacental transmission of HBV infection is observed in a significant proportion of pregnancies, resulting in passive-active immunoprophylaxis failure. In our study we evaluated the efficacy of the currently used passive-active immunoprophylaxis schedule in neonates of HBeAg-negative chronic HBV infected pregnant women, in respect to maternal laboratory data during perinatal period as well as to the presence or absence of HBV-DNA in cord blood samples.
Methods: 76 chronic HBV infected pregnant women were clinically, haematologically, serologically and virologically evaluated during perinatal period. Cord blood was obtained at the time of delivery and the samples were evaluated for the presence of HBV-DNA (Cobas Amplicor HBV Test).
Results: HBV-DNA was detectable in 13 (17.8%) cord blood samples evaluated. Cord blood HBV-DNA positivity was significantly correlated with maternal viral load during perinatal period (p = 0.002). Chronic HBV infected pregnant women with serum HBV-DNA levels higher than 10.000 copies/ml during perinatal period exhibited 5.8 times higher risk of HBV-DNA presence in their cord blood compared to women with serum HBV-DNA lower than 10.000 copies/ml (50% vs 8.6% respectively, p = 0.003). Median cord blood HBV-DNA levels were significantly lower than median maternal serum HBV-DNA levels (316 copies/ml vs 2.667 copies/ml respectively, p < 0.001). None of 44 infants evaluated exhibit immunoprophylaxis failure.
Conclusions: The presence of HBV-DNA in cord blood does not reduce the efficacy of the currently used immunoprophylaxis schedule in neonates of HBeAg-negative chronic HBV infected women.
|Session name:||Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Vienna, Austria, 10 - 13 April 2010|
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