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The relation between the cytokine levels and histopathological activity and fibrosis in chronic hepatitisB and chronic hepatitisC infections

Abstract number: P1139

Tigli A., Akcam F.Z., Kaya O., Ciris M.

Objectives: We ivestigated that possible correlation between the levels of TNF-a, IL-18, IL-10, TGF-b, and INF-g and the Histological Activity Index (HAI) and fibrosis levels in patients with Chronic hepatitis B and C.

Methods: Fifty patients were included in the study. Serum samples were obtained and liver needle biopsy were performed on the same day. Cyctokine levels were investigated by ELISA. Histopathological examinations were carried out by the same pathologist.

Results: There was a statistically significant positive mid-level correlation between TNF-a with HAI and fibrosis (p = 0.004 r = 0.401, p = 0.003 r = 0.407). No significant correlation was found between HAI and fibrosis with IFN-g, IL-10, IL-18, ve TGF-b.

Conclusion: HBV and HCV infections have elaborated pathogenetic mechanisms. The cytokin activity has important impacts on clinical severity and progression. The results obtained in this study shows that further investigations on possible effects of cytokins on hepatocellular damage and fibrosis should be done. Thus, new immunotherapeutic approaches in viral hepatitis may be arranged if this issue is further studied.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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