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Pregnancy and chronic hepatitisB infection: a3year evaluation

Abstract number: P1130

Kurtaran B., Aksu H.S., Candevir A., Inal A.S., Komur S., Tasova Y.

Objectives:Vertical transmission of HBV is an important risk factor for chronic infection in newborns. Pregnant women with positive hepatitis B surface antigen should be screened in the early period of pregnancy. Babies who born to mothers with hepatitis B infection should be immunized after delivery as soon as possible, especially in 24 hours. This study evaluates the risk factors, epidemiology, the progression of disease and the assessment of antiviral treatment for chronic HBV infection during pregnancy.

Methods: Pregnant patients with chronic hepatitis B infection followed in the Department of Infectious Diseases in the Medical School of Çukurova University. The study comprised between January 2007 and March 2009.

Results: Totally 46 pregnant patients were followed with a mean age of 29±6 (number of the patients were 19;19; 8 according to years). Median age of pregnancy was 16 weeks at the time of first visit (minimum 4, maximum 36 weeks). Chronic hepatitis B infection diagnosis was made in 54.4% of the patients before and 45.6% patients during the pregnancy. Eighty three percent of the patients were HBe Ag negative. Family history was positive in 48% of patients and no additional risk factors were found. Delta hepatitis co/super infection was not detected. Median ALT and HBV DNA values in first visit were 22.5 u/L (8–508 u/L) and 857 iu/ml (0–11×107 iu/ml) respectively. Patients of 39% were treated. Patients with or higher than 2000 iu/mL HBV DNA level were treated with lamivudine in the last trimester of their pregnancy. Seven patients had a significant increase in liver disease activity after pregnancy, defined as a three times increase in alanine aminotransferase (ALT) within 6 months after delivery. These seven patients (of those under treatment) used lamivudine during last trimester of their pregnancy. Three patients continued lamivudine for six months after delivery. All newborns vaccinated and applied HBV vaccine and HBIG. Only 30% of those patients and their babies could follow after delivery.

Conclusion: Chronic hepatitis B diagnosed in second trimester of majority pregnant women in spite of family history. Small percent of mothers came to follow up after delivery. This means need more attention and education for family practice.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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