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Six-year study of hepatitisA, B and C infection prevalence in a Greek major hospital

Abstract number: P1121

Karabassi V., Pouyiouka M., Achilleos-Geladaris K., Petrocheilou C., Kiriakaki A., Toutouza M.

Objectives: The purpose of this study was to perform a serological analysis of Hepatitis A, B and C virus (HAV, HBV and HCV) infection prevalence in the patients of a Greek major hospital within a six-year period.

Methods: During the six last years 1/7/2003–30/6/2009, sera from 31580 patients (26180 in-patients and 5400 out-patients), were tested for the detection of HAV, HBV and HCV markers. There were 4 groups of patients, Group A: 10130 patients (7490 in-patients, 2640 out-patients) who were controlled for HBV surface antigen (HBsAg), Group B: 21450 patients (18690 in-patients and 2760 out-patients) who were controlled for the HBV markers: HBsAg, HBeAg, antiHBe, antiHBcore, antiHBs, Group C: 22320 patients (19200 in-patients, 3120 out-patients) who were controlled at the same time for HCV-antibodies and Group D: 3220 patients (2460 in-patients, 760 out-patients) who were controlled for HAV- antibodies (total and IgM). All tests were performed during 2003–2004 by MEIA methodology (AXSYM – Abbott) and during 2005–2009 by immunoluminometric assay method (ARCHITECT – Abbott).

Results: In Group A of the 7490 in-patients and 2640 out-patients were found to be positive for HBsAg 150 (2%) and 82 (3.1%) respectively. In Group B of the 18690 in-patients and 2760 out-patients were respectively: 8728 (46.7%), 1220 (44.2%) seronegative for HBV markers, 1214 (6.5%), 345 (12.5%) positive for HBsAg, 2952 (15.8%), 174 (6.3%) positive for antiHBs due to HBV vaccination, 5794 (31%), 1020 (37%) negative for HBsAg and positive for the rest HBV markers. In Group C of the 19200 in-patients and 3120 out-patients, HCV-antibodies positive was found in 442 (2.3%) and 188 (6%) respectively. 2% of them were at the same time positive for HBsAg. In Group D of the 2460 in-patients and 760 out-patients, HAV- antibodies total positive was found in 1304 (53%) and 388 (51%) and HAV- antibodies IgM positive was found in 50 (2%) and 10 (1.3%) respectively.

Conclusions: This study showed that there is a significant prevalence of HAV, HBV and HCV infection in the patients of our hospital (53%, 37.5%, 2.3% for in-patients, 51%, 49.5%, 6% for out-patients respectively). The effort for the prevention must be continual and the control measures with the systematic Hepatitis A and Hepatitis B vaccination should be strictly enforced.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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