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Epidemiology of hepatitisD virus infection in Bucharest area (HEDDM study)

Abstract number: P1117

Popescu G., Popescu C., Ivan M., Gavriliu L., Antonica D., Paise A., Ducu G., Popa M., Benea E., Streinu-Cercel A.

Several studies indicated a decreasing trend in the hepatitis D virus (HDV) prevalence in different regions. However, in the past twelve years no studies were conducted to evaluate if there is a similar epidemiological change in the Bucharest area.

Objective: This study was undertaken to obtain regional epidemiological data on hepatitis delta virus (HDV) in symptomatic or asymptomatic patients infected with hepatitis B virus (HBV).

Methods: We conducted a cross-sectional study at "Matei Bals" National Institute of Infectious Diseases (Bucharest, Romania), between June 2006 and November 2006. A total of 1094 patients with HBsAg positivity were evaluated for HDV antibodies with SmarTest Diagnostics (Orgenics Ltd, USA). We explored the association between anti-HDV positivity and several epidemiological and clinical parameters; HDV genotypes were evaluated in PCR positive patients.

Results: Anti-HDV was positive in 223 of 1094 patients – 20.38%, CI95% (18.10%; 22.87%), significantly lower than 30.09% in a previous study, p < 10-7. A significant association between the age over 40 years and anti-HDV positivity was found RR = 1.58 (1.19; 2.09), p = 0.0009. Gender, HBeAg positivity, liver disease stage and HIV or HCV co-infection were not significantly associated with anti-HDV presence (p > 0.05). Delta antigen was present in only one patient with anti-HDV antibodies (0.45%). Dual HDV and HBV infection was associated more frequently with elevated ALAT (p = 0.0004), with thrombocytopenia (RR = 8.46, p < 10-7) and with end-stage liver disease RR=6.05 (4.52; 10.42), p < 10-7. All the 26 HDV srains belonged to genotype I.

Conclusion: The results suggest that delta infection remains common in our patients, but a transition towards a decreasing prevalence is possible in Bucharest area. We found a significant relationship between the age of the patients (possible longer HBV infected status) and anti-HDV positivity; delta antigen can not be considered as a marker of HDV replication.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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