Antimicrobial susceptibility of Gram-positive non-urinary isolates to fosfomycin

Abstract number: P941

Objective: We aimed to evaluate the antimicrobial activity of fosfomycin against Gram-positive non-urinary isolates collected at the microbiological laboratory of the University Hospital of Heraklion, Crete, Greece, in 2008.

Methods: We included in our study all Gram-positive clinical isolates originating from sites other than the urinary tract that were collected over a 1-year period (January to December 2008) at the microbiological laboratory of the 700-bed, University Hospital of Heraklion, Heraklion, Crete, Greece.

Results: Susceptibility testing was performed with the disk diffusion method for a total of 1846 isolates; 1275 (69.1%) were susceptible to fosfomycin. Specifically, 416/419 (99.3%) Staphylococcus aureus isolates [including 129/130 methicillin resistant Staphylococcus aureus (MRSA) isolates], and 745/961 (77.5%) coagulase-negative staphylococcal isolates were susceptible to fosfomycin. Among 42 Streptococcus pneumoniae, 64 Streptococcus pyogenes, and 93 other streptococcal isolates, 61.9%, 40.6%, and 48.4%, respectively, were susceptible. Fosfomycin was inactive against the 166 enterococcal isolates tested.

Conclusions: This old antibiotic may deserve consideration for further studies and use in clinical practice, especially for Staphylococcus aureus (including MRSA) infections.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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