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Four major drug-resistant mycobacterial strains isolated between 20012008 in Konya, Turkey

Abstract number: O487

Tuncer I., Turk Dagi H., Solgun G., Yuksekkaya S., Akkaya O., Arslan U., Findik D.

Objectives: In our study, we aimed to detect the presence of M. tuberculosis with the BACTEC 460TB system (2001–2006) and the BACTEC MGIT 960 (Mycobacteria Growth Indicatör Tubes, Becton-Dickenson) system (2007–2008) in clinical samples containing suspected pulmonary and extrapulmonary tuberculosis and also to determine the resistance of the isolated M. tuberculosis strains against four major antimicrobial drugs. The study period was between 2001 and 2008.

Methods: From 2001 to 2006, antimicrobial susceptibility tests to isoniazid (INH), streptomycin (SM), ethambutol (EMB) and rifampin (RIF) on 635 Mycobacterial strains were performed using the radiometric BACTEC 460TB system. From 2007 to 2008, antimicrobial susceptibility tests on 270 Mycobacterial strains were performed with the BACTEC MGIT 960 SIRE kit.

Results: Of the 1039 M.tbc spp., antibiotic susceptibility tests were performed on 905. We observed that 84.8% (767/905) were susceptible to all 4 antibiotics, 15.2% (138/767) were resistant to at least one of the 4 antibiotics. Mono resistance rates to INH, SM, RIF, and EMB were 4.4, 1.3, 0.6 and 0.4, respectively. Total monodrug resistance was observed in 6.7% of 905 the Mycobacterial isolates. Resistance to two drugs was observed in 48 (5.3%) isolates, to three drugs in 24 (2.7%) isolates and to four drugs in 5 (0.5%) isolates. The prevalence of MDR (Multidrug Resistance) in 905 Mycobacterial isolates was 4% (36/905).

Conclusions: According to these results it could be concluded that, drug resistance which requires immediate solution, continues to be a major problem in our region.

Figure. The annual numbers of culture-positive specimens, the number of susceptibility tested cultures, the number of cultures suceptible to four drugs tested, the number of cultures resistant to at least one drug from 2001 to 2008.

Session Details

Date: 10/04/2010
Time: 00:00-00:00
Session name: Abstracts 20th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Vienna, Austria, 10 - 13 April 2010
Presentation type:
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