Murine typhus in a paediatric hospital in Greece

Abstract number: R2292

Antonaki G., Tsialta P., Sergiou Z., Ganouri T., Kallergi K.

Objectives: The aim of this study is to present the clinical and epidemiological characteristics of Rickettsia typhi infection in children, during the last five years.

Methods: Between October 2003 and October 2008, 496 children under 15 years of age, admitted to our hospital with fever, were tested for Rickettsia typhi infection. For the serological diagnosis an indirect immunoflorescence assay was used.

Results: Serological diagnosis of acute Rickettsia typhi infection (IgM antibody titers of 64 or higher and IgG antibody titers of 256 or higher to typhus group antigen) was found in 17 children (9 boys and 8 girls, median age 11 years). The most frequent manifestations of rickettsial disease were fever (100%) and rash (41%). Rash appeared as maculopapular or erythematous. Splenomegaly (29%) and lymphadenopathy (18%) were noted less frequently. Abnormal laboratory findings included mild elevation of liver enzymes, anaemia, leukopenia and thrombocytopenia. Most of the cases presented at fall (88%). The residence of the majority of the children was in the provinve or in the suburban area of Attica (76%).

Conclusion: Murine typhus is rare in children, usually presented in fall months with fever and rash. Serological tests in symptomatic children from endemic areas should be performed.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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