Real practice of antimicrobials use in the treatment of sexually transmitted diseases in Russia
Abstract number: R2285
Belkova Y.A., Aleksandrova O.Y., Berezhanskiy B.V., Bochanova E.N., Chebotarev V.V., Chechula I.L., Dekhnich A.V., Eliseeva E.V., Ortenberg E.A., Savicheva A.M., Toropova I.A., Kozlov R.S.
Objectives: Prompt treatment of sexually transmitted diseases (STDs) is an essential component of their control. So, we aimed to reveal real practice of treatment of bacterial STDs throughout Russia.
Methods: A multicentre retrospective study was conducted in 10 different cities of Russia. Clinical records of adult patients treated for bacterial STDs during Jan 2007Dec 2007 were collected.
Results: The data on 1250 patients (61% male, 39% female, mean age 28.8±9.2) with: early syphilis (n = 341), uncomplicated gonococcal (n = 309), chlamydial (n = 310), mycoplasmic (n = 137) and ureaplasmic (n = 153) infection were analyzed. Overall 1567 disease orientated prescriptions were registered. Antimicrobials accounted for 1352 (86.3%) and were represented by six groups: macrolides (30%), cephalosporins I-III (22%), penicillins (19.5%), tetracyclines (15.1%), fluoroquinolones (9.5%), aminoglycosides (4%). Early syphilis was commonly treated by benzathine penicillin (38.4%), procaine penicillin (28.3%), ceftriaxone (26.9%) and penicillin G (5.5%); gonococcal infection by ceftriaxone (57.5%), spectinomycin (9.3%), doxycycline (7.2%), azithromycin (5.1%); chlamydial infection by azithromycin (28.2%), doxycycline (22.2%), claritromycin (14.9%), josamycin (11.1%), ofloxacin (7.9%); mycoplasmic and ureaplasmic infection by doxycycline (31.8%), josamycin (21.3%), azithromycin (13.1%), claritromycin (12.8%), levofloxacin (5.6%). Other agents accounted for less than 5% each. Administered therapy went in conflict with modern national guidelines in 28.2% of patients, international guidelines in 24.2%. Among correctly chosen agents only 24% and 11%, respectively, were used in recommended course doses (higher dose 69.1% and 83.7%, lower 6.9% and 5.3%).
Conclusion: Relatively low compliance to national and international guidelines as well as existing tendency to use antibiotics in higher then recommended course doses require administrative actions to change this situation throughout our country.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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