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Therapeutical approach in hydatic cyst disease with multiple location

Abstract number: R2240

Stoicescu R., Mihai C.M., Catrinoiu D., Balasa A., Mihai L., Cuzic V., Sirbu R., Negreanu T., Arcus M.

Background: Hydatid liver, pulmonary, cerebral and peritoneal disease in children is a serious problem, mainly in areas where the parasite is endemic.

Echinococcosis is a severe disease in childhood inaccessible to an initial radical surgical treatment, medical therapy being an alternative with controversial curative efficacy.

Objective: to evaluate the efficacy of albendazole and to discuss the role of surgery in multiple hidatid cyst disease diagnosed in 29 patients.

Material and Method: The group of study was represented by 14 children aged 2–16 years and 15 adults, mean age 35.4 years, treated in two county hospitals in Constanta between 2000 and 2008.

All patients had multiple hepatic cysts and 12 had coexisting cysts in the lung.

One patient had a peritoneal cyst, 2 had cerebral cysts and 1 had multiple located cysts (liver, brain, lungs and heart).

In 19 cases, medication with albendazole was used as the initial therapy, given as 10 mg/kg daily continuously, for several months (3–9 months).

Results: The overall success (defined as progressive shrinkage and solidification of the cyst) of medical therapy was very low, 1 patient with 2 pulmonary cysts was cured. Age, sex, and the size, location, and number of cysts did not show any relationship to the response to medical therapy. A total of 28 patients (10 primarily, 18 after unsuccessful medical therapy) were treated surgically. During the follow-up period, 3 surgical patients(2 untreated and 1 treated with albendazole), developed recurrent disease.

Conclusion: Medical treatment with albendazole resulted in fewer curative successes than expected; probably a longer period of medical treatment may increase the success rate, coupled with surgery.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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