Novel antifungal phenolic compound from Parrotia persica

Abstract number: R2138

Ahanjan M., Ragavendera M., Raveesha K.

Aqueous and methanol extracts of Parrotia persica leaves were assayed for antifungal activity against phytopathogenic Fusarium oxysporum and human pathogenic Candida albicans by poisoned food technique. Both the aqueous and methanol extracts demonstrated significant antifungal activity. Further fractionation of methanol extract guided by antifungal activity resulted in the isolation of an active principle which was identified as phenolic compound by phytochemical analysis. The structure of the active principle was elucidated by Mass spectroscopy, 1H NMR and 13C NMR spectroscopy. These results revealed that the compound is 6-(ethoxymethyl)-tetrahydro-2H-pyran-2, 3, 4, 5-tetraol compound with 1-isopropyl-4-methoxybenzene. The compound was found responsible for antifungal activity against both F. oxysporum and Candida albicans.

Figure: Structure of the active principle [6-ethoxy­methyl)-tetrahydro-2H-pyran-2,3,4,5-.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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