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Crimean-Congo haemorrhagic fever in Kosova, 19892008

Abstract number: P2050

Ahmeti S.A.

Crimean-Congo Haemorrhagic Fever (CCHF) is acute viral zoonossis that appears after tick bit in endemic areas during months April-July.

Objectives: The aim of this study was to represent special clinical, epidemiological and laboratory characteristics of CCHF in our cases caused by native Hoti-Kosova virus.

Methods: There are studied 207 patients with Crimean-Congo haemorrhagic fever serologically confirmed (from totally 564 cases with clinical manifestations) which are treated at the Infectious Diseases Clinic of the University Clinical Center of Kosova during period 1989–2008. Diagnosis of the disease is set based on epidemiological, clinical and laboratory data and is confirmed by serological-viral tests (ELISA, RT-PCR).

Results: With viral examinations, in cooperation with Microbiological Institute of Ljubljana, is isolated a new virus, causer of CCHF in Kosova and is nominated Hoti-Kosova virus, which is different in phylogenesis from other regional types of CCHF viruses. Infection is caused after tick bit. Human transmission is found in 21.2% cases inside family, and in 2.42% of cases between health personnel. Infection is more frequent in males (57.9%) than in females. Diseases has shown severe course with intensive haemorrhagic manifestations: petechie (69.3%), bloody eyeball (49.2%), epistaxis (62.4%), haematemesis (70.5%), melena (78.2%), haematuria (29.2%), metrorrhagia (34.5%), liver disorders like hepatitis and mild renal disorders. Specific manifestations in our cases are: otorrhagia (2.03%), Herpes Febrilis (6.6%), haematoperitoneum (13.2%), pleuritis haemorrhagica (5.6%), pericarditis haemorrhagica (8.6%) and thrombocitosis during period of convalescence (1.5%). There has been high rate of Fatality (23.83%).

Conclusion: Republic of Kosova is endemic zone for CCHF. Disease is caused from native type of virus Hoti-Kosova, closely related to a CCHF virus strain Drosdov. Course of the disease has been severe with specific clinical manifestations and with high Fatality Rate.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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