Delta hepatitis infection in patients with chronic hepatitisB infection in Isfahan, Iran
Abstract number: P2003
Ataei B., Kalantari H., Soleimani S., Javadi A., Adibi P., Yaran M., Nokhodian Z., Ataie M.
Introduction: Hepatitis D virus is a defective RNA virus dependent on hepatitis B virus infection for its replication and expression. Infection with HDV can occur simultaneously with acute HBV infection or may be superimposed on chronic HBV infection. It is known that coexistent infection with HBV infection with HDV tend to accelerate the progress of chronic HBV infection to chronic hepatitis, cirrhosis and hepatocellular carcinoma. This study was carried out to determine the seroprevalence of HDV among chronic hepatitis B patient in Isfahan in year 2008.
Materials and Methods: This study was done at first 7 month of year 2008 and was cross-sectional and done among 347 chronic hepatitis B patients that got along more than six months from their diagnosis and had medical file at infectious disease and tropical medical research centre. All Case were evaluated for the presence of total HDV Ab using Elisa (Diapro-Italy). Chi-square and Fisher test and T-student was used to determine the relationship between independent variables and HDV seropositivity.
Results: Of 347 cases 246 were male (70.9%) and 101 were female (29.1%). 232 were Anti HBe positive (66.9%) with mean age 41.2±11.8 and 88 were HBe Ag positive (25.4%) with mean age 34.6±12.8. Anti-HDV Anti body was positive in 6 male (2.4%) and in 4 female (4%) (P = 0.48). Anti HDV Ab was positive in 8 Anti HBe positive (3.4%) and in 2 HBe Ag positive (P= 0.5). The mean age in HDV Ab positive patients was 43.9±12.4 years. Mean long duration disease in HDV Ab positive patients was3.5±2.7 years. The total seroprevalence of HDV Ab in hole patients was 2.9%.
Conclusion: This Findings show that HDV infection is endemic in Isfahan province and its prevalence is high in HBe Ab positive patients than HBe Ag positive patients. We found no relationship between HDV seropositivity and age, sex, long duration of disease and kind of diagnosis and transmission. The seroprevalance of hepatitis D in this study at compare previous study in Iran is nearly equal.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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