Comparison of the effects of ciprofloxacin, cotrimoxazole, amoxicillin, and chloramphenicol in patients with typhoid fever

Abstract number: P1783

Mahmood I., Abdullah K.

Objectives: To compare the effects of ciprofloxacin, chloramphenicol, cotrimoxazole and amoxicillin in patients with typhoid fever.

Methods: Ninety three patients with symptoms and signs of typhoid fever and positive Widal test participated initially in the study. Seven patients were excluded from the study because of loss of follow-up and the final results were thus obtained from the remaining 86 patients.

The main symptoms and signs reported at the start of the study were fever, headache, malaise, anorexia, abdominal pain, dry cough and splenomegaly. Widal test was positive in all patients which revealed 4 to 8 folds increase in the titer of antibodies against O and H antigens of Salmonella typhi.

The response to therapy was evaluated by: time taken to defervescence and the improvement of the patient's condition. The later was defined as the improvement of the GIT symptoms, improvement or disappearance of headache, improvement of general conditions of the patients, and the patient's survival without a major complications.

Results: Duration of illness before antimicrobial administration were 10.43, 10.48, 11.15, and 10.64 days for ciprofloxacin, cotrimoxazole, amoxicillin and chloramphenicol groups, respectively. No statistical differences in the duration of the illness were found before therapy among the 4 treatment groups.

The mean time of defervescence for ciprofloxacin group was 3.74 days, for amoxicillin group 5.9 days, for cotrimoxazole group 6 days and 5.2 days for chloramphenicol group. Time taken for defervescence was significantly shorter in those treated with ciprofloxacin as compared with patients given cotrimoxazole, amoxicillin or chloramphenicol. Time taken for clinical improvement was significantly shorter in those treated with ciprofloxacin (6.2 days) as compared with those taken cotrimoxazole (10.05days), amoxicillin (9.8 days) or chloramphenicol (8.32 days).

Conclusion: ciprofloxacin is a better drug for the treatment of patients with typhoid fever as it significantly reduces fever and other symptoms within a shorter time as compared with cotrimoxazole, amoxicillin or chloramphenicol.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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