Trends in invasive groupA streptococci in adult patients in Barcelona

Abstract number: P1727

Ardanuy C., Rolo D., Domenech A., Tubau F., Ayats J., Grau I., Pallares R., Martin R., Liñares J.

Objective: The aim of this study was to analyze the invasive disease due to Streptococcus pyogenes (GAS) in adults patients during a ten-year period (1998–2007) in Barcelona.

Methods: All invasive GAS episodes detected in our hospital were collected. Antibiotic susceptibility was studied by microdilution. Molecular typing was performed by PFGE (SmaI) and emm-typing and selected strains were studied by MLST.

Results: A total of 127 episodes of invasive GAS disease were observed during the study period. Of them, 76 occurred in men (60%). The medium age was 57 (SD19.7, range 18–98). The overall incidence of invasive GAS disease was 2.2 episodes per 100,000 inhabitants. Among people older than 65 the invasive GAS disease (6.4/100,000) was higher than those observed among adults aged 18–64 years (1.4/100,000, p < 0.001). The sources of invasive GAS were blood 110 (87%), joint fluid 9 (7%), pleural fluid 7 (6%), and ascitic fluid 1 (0.8%). Most of invasive diseases were related to soft-tissue infections. The antibiotic resistance rates were as follows: erythromycin 20.5%, clindamycin 12.6%, tetracycline 17% and ciprofloxacin 2%. All strains were susceptible to penicillin. Ninety-five strains were available for molecular typing. The six most frequent emm types and their related sequence-types (STs) were emm1-ST28 (31%), emm59-ST172 (10%), emm28-ST52 (6%), emm4-ST39 (5%) emm12-ST36 (5%) and emm25-ST350 (5%).

Conclusion: The majority of invasive infections caused by Streptococcus pyogenes in adult patients in our area were related to soft-tissue infections and were associated with emm1-ST28 type, whereas the emm59-ST172 and emm25-ST350 types were mainly associated with injection drug users.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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