Activity of tigecycline and five comparators against recent Gram-positive anaerobes in Europe the Tigecycline European Surveillance Trial
Abstract number: P1604
Hackel M., Bouchillon S., Johnson B., Hoban D., Renteria M., Johnson J., Badal R., Hawser S., Dowzicky M.
Objectives: Tigecycline is a novel antimicrobial with expanded broad-spectrum activity from a new class of compounds, the glycylcyclines. Tigecycline was developed to provide activity against tetracycline and multi-drug-resistant Gram-positive pathogens and has demonstrated significant broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative microorganisms. In this study we evaluated tigecycline and five comparator compounds against European Gram-positive anaerobic isolates.
Methods: 454 Gram-positive anaerobic pathogens were collected and identified from 18 sites in 6 countries in Europe. MICs of tigecycline and five comparators were determined per EUCAST guidelines using agar dilution.
Results: European Gram-positive pathogens tested against tigecycline and comparators are shown in the table.
Conclusions: Tigecycline showed excellent in vitro activity against Gram-positive anaerobic microorganisms isolated from European hospitals. MIC50 values for tigecycline against all isolates tested were <0.06 mcg/mL, while MIC90 values were <0.5 mcg/mL. Using the FDA breakpoint of <4 mcg/mL, 100% of the isolates were susceptible to tigecycline, including difficult to treat Clostridium difficile.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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