Erectile dysfunction in HIV+ male patients
Abstract number: P1287
Katsarolis I., Protopapas K., Panagopoulos P., Poulakou G., Sakka V., Galani L., Kavatha D., Papadopoulos A., Antoniadou A.
Objectives: To assess the prevalence of ED and to identify potential risk factors in a HIV(+) male population.
Methods: For a 3 month period, the "International Index for Erectile Function" questionnaire (IIEF) was distributed to HIV+ male pts attending the outpatient clinic for regular follow-up. Pts with recent HAART initiation (<6 mos), recent hospital admission (<1 mo) and recent HIV diagnosis (<1 y) were excluded. For each pt, ED was assessed by the IIEF score. Demographic information, clinical data (HAART history, comorbidities) and lab data were recorded (CD4 count, viral load expressed as logVL, thyroid function tests, FSH/LH, prolactin and testosterone serum levels, lipid profile). Mann-Whitney and Kruskal-WallisH tests were applied for quantitative data and chi-square test for qualitative data. Variables with P value <0.1 were entered in a multivariate logistic regression stepwise model, calculating odds ratios(OR), 95% confidence intervals(95%CI). P values 0.05 were considered as statistically significant. Informed consent was obtained from each patient enrolled.
Results: Fifty pts were originally enrolled, and 47 provided a properly filled questionnaire. Mean pt age(±SD) was 39±11.2 ys with mean CD4 count(±SD) 518±13.7 cells/mm3 and logVL(±SD) 2.7±1.2. Thirteen pts were not actively on HAART (23.6%). Half of the pts had undetectable viral load (logVL 1.7). No pt had a history of hypertension, coronary heart disease or psychiatric illness. Smoking was reported in 30%. In 21/47 pts (44.7%) ED of any degree was revealed. Prevalence of ED was 21% for pts <35 ys, 55% for those 3650 ys and 75% for pts >50 ys. Risk factors identified by univariate analysis were age (P = 0.009), nadir CD4 count (P = 0.017), history of AIDS (P = 0.023), more than one HAART regimens (P = 0.023) and actively receiving a PI-based regimen (P = 0.021). No difference was identified in the other haematological and biochemical parameters tested. From the multivariate analysis, age (for pts <35 ys, OR 0.104, 95%CI 0.0200.537, P = 0.007) and nadir CD4 count (for <200 cells/mm3 OR 22.121, 95%CI 1.212403.728, P = 0.037) displayed significant association with the presence of ED.
Conclusions: ED is prevalent among HIV+ male pts, presenting at an earlier age than the general population. Pts with lower nadir CD4 counts and age >35 years present more frequently with ED. A larger number of pts will help elucidate other possible risk factors associated with the presence of ED in HIV+ pts.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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