Non-vaccine HPV types are frequent in HIVpositive subjects
Abstract number: P1284
Protopapas K., Tsiodras S., Chranioti K., Papadopoulos A., Antoniadou A., Sakka V., Galani L., Panagopoulos P., Georgoulakis J., Kavatha D., Koukos G., Katsarolis I., Spathis A., Karakitsos P., Giamarellou H.
Introduction: We examined anal HPV infection in a cohort of HIV infected patients and correlated cytological findings with molecular findings and immunological parameters.
Methods: Prospective follow-up with Thin prep anal smear testing is performed in all patients of an tertiary care centre HIV clinic. Clinical arrays are used to identify HPV infection. Univariate and multivariate analysis was used to identify associations between HPV detection and demographics, cytological changes and immunological parameters.
Results: 105 pts [92.3% male, median age 38 yrs (IQR: 30.344.8)] with a median duration of HIV infection of 3 yrs (IQR: 17.8 yrs) have been examined. Mean value of current CD4 was 419/mm3 (IQR: 284.5593.8) and of current HIV viral load was 364.5 c/mL (IQR: non detected-9880 c/mL, 48/105 <50 c/mL). Cytological changes were detected in 61.5% of the population. AIN1, AIN2, and AIN3 were diagnosed in 3.7%, 1.2% and 2.5% of the population respectively. HPV was detected with clinical arrays in 92.4% of the population (69.2% low risk types, 83.3% high risk types, 59.1% mixed low and high risk types). Most frequent types detected were HPV types 6 (40%), 53 (39%), 51 (28.5%), 11 (25.7%), 66 (22.8%), 70 (21%), eae 18 (19%). Diagnosis of a cytological lesion were associated with HPV detection (p = 0.01). HPV positivity was associated with decreasing age (p = 0.02), n of sexual partners (p = 0.045), and lower CD4 counts (p = 0.02).
Conclusions: HPV infection was prevalent in this patient cohort. Non vaccine HPV types predominated. Immunological correlates of HIV infection appear to be important in the evolution of anal cytological changes. Prospective follow-up of HIV pts with HPV is necessary for the prevention of perianal malignancies.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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