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Relationship between prevalence of peptic ulcer and cagA/iceA genotypes of Helicobacter pylori

Abstract number: P1243

Alipourfard I., Mahmoodi S.

Objectives: To determine the prevalence of cagA/iceA genotypes Helicobacter pylori (H. pylori) isolated from a group of Iranian patients with gastric complaints, and to find out any significant correlation between these strains and severe gastric clinical outcomes such as peptic ulcer and gastric cancer in Iranien population.

Methods: A total of 918 gastric biopsies from 306 patients who presented with symptoms suggestive of chronic gastritis, peptic ulcer disease, or gastric carcinoma were taken from big and main hospitals in the northern region of Tehran from March 2007 to September 2008. We cultured the samples for H. pylori and then polymerase chain reaction (PCR) was carried out to check for the presence or absence of cagA gene the status of iceA genotypes.

Results: Among the 306 suspected to be infected with H. pylori by means of clinical features and endoscopic findings; 70 patients (23%) were positive using culture technique. Also use of PCR for determine of the cagA gene in these samples showed the relation of the presence of cagA and the development of cases of gastritis and ulcer was statistically significant (p = 0.0001). Furthermore, this study revealed that 98.2% of ulcer cases were infected with iceA1 with a statistically significant correlation (p = 0.0001), while 92.5% of gastritis and 88.1% of normal were infected with iceA2 (p = 0.0001). Moreover cagA+/iceA1 combined genotypes was statistically correlated with peptic ulcer (100%) but not cagA-/iceA1 (0%;p = 0.0001).

Conclusion: Certain H. pylori genotypes were more virulent than others. Multiple clinical implications based on these finding might be studied further.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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