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Study of effectiveness and antimicrobial activity of an alcohol-free, non-rinse antiseptic developed for skin disinfection in emergency situations

Abstract number: P1149

Lozhkina O., Savinov A., Afinogenova A., Afinogenov G.

Objectives: After an emergency, it can be difficult to find running water. However it is still important to clean your hands to avoid illness. The aim of this study was to investigate effectiveness and biocidal activity of an alcohol-free, nonrinse antiseptic combination containing as active substances polyhexamethyleneguanidine phosphate (0.8%) and quaternary ammonium compounds (0.35%) and to show its advantages in respect to alcohol-based formulations for hygienic skin disinfection in emergency situations.

Methods: The effectiveness of the formulation and its sustained effect were tested by the swab method in a cross-over design with 40 volunteers in 5 hospitals in St. Petersburg. Biocidal activity was tested against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Mycobacterium B5 and Hepatitis B virus using standard cambric test-objects method.

Results: The level of natural microflora decreased for 98.5 at hygienic hand treatment with 2 ml of the formulation and for 98.8 at hygienic hand treatment with 3 ml of the formulation. The time of treatment was at least 1 minute in both cases. It was also demonstrated that the combination had a 100% 3-hours long sustained effect and was bactericidal against S. aureus, E. coli, Ps. aeruginosa and virulicidal against Hepatitis B virus in 15 seconds, fungicidal against C. albicans and tuberculocidal against Mycobacterium B5 in 1 minute and virulicidal against Polyovirus type 1 in 3 minutes.

Conclusion: The present formulation demonstrated a wide spectrum of antimicrobial activity and excellent acceptance. Due to its unique properties, it meets all regulatory requirements for multipurpose skin sanitizers. On the contrast to the alcohol-based skin antiseptics, it is non-flammable, doesn't have any skin irritating effect even at a frequent use and has a 3 hours-long sustained effect. It is powerful to prevent spreading of infection among people in emergency conditions when clean water is anavailable.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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