Surveillance of antimicrobial consumption patterns in high complexity hospitals in Colombia,20022007

Abstract number: P752

Buitrago G., Castillo J.S., Leal A.L., Alvarez C.A., Cortes J.A., Meneses A.F.

Objectives: Describe novel information about antimicrobial consumption patterns in a reference hospital wide network in Colombia

Methods: Surveillance of antimicrobial consumption prescribed in hospitals (intravenous indications) of ten wide used antibiotics in the country, from january 2002 to december 2007. The following antimicrobials were studied: amikacin, ampicillin/sulbactam, cefepime, ceftazidime, ceftriaxone, ciprofloxacin, clindamycin, imipenem, meropenem, oxacillin, piperacillin/tazobactam, vancomycin. Ten reference hospitals from five most important cities in the country including capital city reported antimicrobial consumption in milligrams from pharmacy registers, prescribed drugs were grouped as the number of defined daily doses (DDD) per 100 bed-days (World Health Organization). Information in DDD per 100 bed-days was monthly grouped. All descriptive analysis were performed, we describe temporal patterns using time series analysis of median consumption for each month (72 periods).

Results: ten hospitals at the end of the observation period notified antimicrobial consumption information. There is an important decrease in general use of ciprofloxacin and the reject of ceftazidime use from 2004. An upward trend can be observed and predicted for ampicillin/sulbactam, ceftriaxone, meropenem, piperacillin/tazobactam and vancomycin. The rising in meropenem use is set in contrast with imipenem steady trend. Trends of some antibiotics are shown graphically in Figure 1.

Conclusions: antimicrobial consumption surveillance is a main step in antimicrobial stewardship programs design. The Nosocomial antibiotic use patterns could be reflecting the effect of rational use strategies in studied hospitals, microbiological profiles and antimicrobial availability conditions. This first report of antimicrobial consumption in hospitals in our country establishes the need for further research in the antimicrobial use and the relationship with antimicrobial resistance and the identification of determinants to direct control strategies.

Figure 1. Antimicrobial consumption trends in DDD per 100 bed-days. Colombia, 2002–2007.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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