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Comparison effect of vitaminC vaginal tablet with metronidazole vaginal gel treatment and relapse of bacterial vaginosis

Abstract number: P744

Abbaspoor Z.

Introduction: Bacterial vaginosis is the common cause of abnormal vaginal discharge among women of reproductive ages.

Objective: This is a randomised clinical trial study to compare the effect of vitamin C vaginal tablet with metronidazol gel in treatment of symptomatic bacterial Vaginosis.

Methods: After confirmed diagnosis of bacterial vaginosis to Amsel criteria (at least 3 out of the 4 characteristic symptoms discharge, fishy odour, vaginal pH geqslant R: gt-or-equal, slanted 4.5, and presence >20% of clue cell), 60 non pregnant women of 15–45 years of reproductive ages enrolled in randomised clinical study. The women were randomly assigned to receive either 250 mg vaginal tablet vitamin C once daily for 6 days (n = 30) or vaginal gel 0.75% metronidazol 5 gr once daily for 5 days (n = 30). The two groups resulted comparable for demographics, history and baseline clinical picture. Participants were evaluated in two follow-up visits (after treatment and two week after treatment). Therapeutic success was defined as the presence of less than three of Amsels criteria.

Results: At the first follow-up visit, 23 (76.7%) of women in vitamin C group and 24 (80%) in metro gel group were cured (P = 0.7). At second follow-up visit two women (9.5%) in vitamin C group and one (5%) in metro gel group bacterial vaginosis was relapse (P = 0.999). Three women in vitamin C group and four in metro gel group were reported occasional burring and itching during product use.

Conclusion: Vitamin C vaginal tablet 250 mg has effectiveness as metronidazol vaginal gel for treatment of bacterial vaginosis.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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