Temporary changes in the frequency of extended espectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae in Colombia,20022008
Abstract number: P667
Meneses A., Buitrago G., Cortes J., Leal A., Castillo J., Alvarez C.
Objective: To describe the trend in time of the frequency of E. coli and K. pneumoniae isolates with extended beta lactamase (ESBL) production in colombian thrid level hospitals.
Methods: A time series analysis of E. coli and K. pneumoniae ESBL producers, obtained in clinical samples from hospitalised patients in 9 third level hospitals in 2 cities in Colombia (Bogota and Ibague) between january 2002 and june 2008. All the isolates had an ESBL confirmed by use of automated microbiological Vitek system (Lyon, Biomerieux). Data was systematised with Whonet 5.4®. Isolates were characterised according to ward type (ICU vs. non ICU) and sample type. Monthly information (78 consecutive periods) was analysed with time series methodology (Box Jenkins) for each microorganism according to its localisation. With the best model, forecasts were realised for the next 12 months with confidence intervals of 95% by means of Statgraphics Centurión XV® software.
Figure 1. Time series and forecasting for ESBL-producing Enterobacteriaceae. GREBO 20022008.
Results: 14055 E. coli isolates and 4627 K. pneumoniae isolates were analysed. Global frequency of ESBL production was 6.9% (n = 976) for E. coli (samples were most frequently obtained from urine 48.5%, secretions 14.3%, blood 8.2%, faeces 6.9% and dialytic fluid 4.8%). ESBL were found in 27.81% (n = 1287) of K. pneumoniae isolates (obtained in 29% from urine, 22% from blood, 11.7% form secretions 8.4% from catheters and 7% from faeces). Annual frequency for ESBL in E. coli from the years 2002, 2003, 2004, 2005, 2006, 2007 and the first semester of 2008 were 8.1%, 9.1%, 6.7%, 7.1%, 6.1%, 6.3% and 7.4%, respectively. ESBL was found in K. pneumoniae, for the same years, with a frequency of 39.3%, 34.8%, 28.6%, 33.6%, 27.0%, 22.5% and 18.1%, respectively. Time series models and the forecast for the next 12 months is showed in the figure 1.
Conclusions: There is trend for a lower rate of ESBL isolates among K. pneumoniae in ICU and non ICU samples. The frequency of ESBL producers in E. coli has remained stable and there is slight increase for the last 18 months in non-ICU wards. The forecast for the latter is remain in a similar level.
|Session name:||19th European Congress of Clinical Microbiology and Infectious Diseases|
|Location:||Helsinki, Finland, 16 - 19 May 2009|
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