Bacteraemia by extended-spectrum beta-lactamase-producing Escherichia coli as a complication after endoscopic retrograde cholangiopancreatography

Abstract number: P660

Rodriguez-Guardado A., Alonso P., Perez F., Fleites A., Lantero M., Cartón J.

Background: The present was performed to describe the characteristics of bacteraemias by Extended-spectrum beta-lactamase-producing Escherichia coli following cholangiopancreatography and the methods of prevention and treatment of the same.

Methods: Thirteen different episodes of bacteraemia by Extended-spectrum beta-lactamase-producing Escherichia coli were retrospectively studied in patients submitted to endoscopic cholangiopancreatography (ERCP) from 2006–2008. All the patients received antimicrobial prophylaxis with piperacillin-tazobactan (4.5 gr/8 hours during 24 hours).

Results: Thirteen patients (3.6% of the patients undergoing ERCP) presented episodes of bacteraemias by the microorganism in the 48 hours following the procedure. 53.6% were male, mean age 70 years, limits 44–85). A biliar prosthesis was put during the procedure in eight patients. All the patients presented obstructive disease in the form of calculi or neoplasms at the level of the biliary tree. All the patients showed typical clinical manifestations of cholangitis. One patient (7.7%) died as a consequence of bacteraemia and a hepatic abscess was developed in other case. The prosthesis was removal on trhee cases.

Conclusions: Bacteraemia by Extended-spectrum beta-lactamase-producing Escherichia coli following ERCP is more frequent in patients with obstructive disease of the biliary tract and has an important additional morbimortality. The use of drugs with an betalactamase-inhibitor as preendoscopic prophylaxis probably should be considered as predisposing factors.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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