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Distribution of genotypes of human papilloma virus in women from different countries

Abstract number: P577

Alvarez-Argüelles M.E., Melon S., Villa L., Palacio A., Boga J.A., Junquera M., Mejuto P., De Oña M.

The aim of this study was to determine the distribution of genotypes of HPV in women from different countries attending a consultation as part of an STI control program and screening of HPV infection.

Patients and Methods: Between 2000 and 2007 are being studied 2067 samples brushed endocervical of 1201 women (average age 28.9±7.8 years, range 18–75) from: Brazil 472 (817 samples), 360 rest of Latin America (648 samples), 248 were born in Spain (382 samples), 67 from Eastern Europe (128 samples) and 54 sub-Saharan Africa (92 samples). HPV detection was performed using a PCR fragments compared to L1 and E6/E7. The positive samples were characterised using hybridisation with probes labeled with 32P for 6/11/16/18/31/33/45/58 genotypes.

Results: HPV was found in 148 (31.3%) women in Brazil, 96 (27%) of Latin America, in 75 (30%) of Spain, 20 (29.8%) from Eastern Europe and 11 (20.4%) from Africa.

The distribution of genotypes (in percentage) is found in the table.

The percentage of vaccine genotypes (HR and BR) ranged between 42 and 73%. The HPV 16 and 18 ranged between 40 and 52% of all high-risk genotypes (Africa not included).

Conclusions:

–The prevalence of HPV infection was similar in all groups.

–The 16 genotype was distributed equally in all countries included in this study.

–The 18 genotype was less common in Spanish women.

–The genotype was detected in only 45 women in Latin America.

–The high-risk genotypes vaccine account for half of oncogenic genotypes detected.

 VPH6VPH11VPH16VPH18VPH31VPH33VPH45VPH58VPH NTCoinfection
Brazil8.7811.4925.689.4614.866.762.0310.8137.1618.92
Latin America11.469.3813.548.3310.427.291.0410.4253.137.29
Spain30.6717.33241.33122.670834.6712
Eastern Europe30101555150104025
Africa9.099.0927.279.099.0900045.459.09

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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