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Rotavirus gastroenteritis in Norway: analysis of prospective surveillance and hospital registry data

Abstract number: O472

Flem E., Vainio K., Døllner H., Midgaard C., Bosse F.J., Wesenberg Rognlien A.G., Rojahn A., Nordbo S., Størvold G., Njølstad G., Wathne K.O., Konsmo K., Aavitsland P.

Objectives: We examined the epidemiology and burden of rotavirus gastroenteritis in Norway to inform the national decision on introducing new rotavirus vaccines into routine immunisation.

Methods: We reviewed the national hospital registry data on children <5 years of age hospitalised with acute gastroenteritis (AGE) during January 1995–December 2004. We also conducted sentinel rotavirus surveillance among children <5 years of age admitted with AGE to three large hospitals during 2006–2008, and examined the numbers of rotavirus-positive tests reported to the national laboratory surveillance system in 1995–2004.

Results: During 1995–2004, 14973 gastroenteritis hospitalisations were reported for an annual rate of 4.9 (95% confidence interval (CI) 4.6–5.3) hospitalisations per 1000 children. The proportion of AGE hospitalisations with rotavirus-specific code on the discharge records was 14%. However, sentinel surveillance determined that 63% (95% CI 57.4–68.3) of these hospitalisations were associated with rotavirus, yielding an estimated annual incidence of 3 (95% CI 2.6–3.5) rotavirus hospitalisations per 1000 children, corresponding to ~906 (range 735–1092) hospitalisations annually. Children aged 6–23 months accounted for 61% of all confirmed rotavirus cases. Rotavirus hospitalisations demonstrated distinct spring seasonality. No rotavirus-associated deaths were reported during sentinel surveillance or in the hospital registry data.

Conclusions: Estimated two thirds of all gastroenteritis hospitalisations in children <5 years of age in Norway are attributable to rotavirus. This report provides the first data on rotavirus epidemiology and disease burden in Norway. Further studies are needed to assess the economic impact of rotavirus disease and the cost-effectiveness of vaccination to inform decisions on introduction of rotavirus vaccines into the national program of childhood immunisation.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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