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The ESAC Point Prevalence Survey of patterns of antibiotic use in 50 European hospitals in 2008

Abstract number: O294

Muller A., Amadeo B., Hendrickx E., Vankerckhoven V., Davey P., Goossens H.

Objectives: To perform a Point Prevalence Study (PPS) on antimicrobial prescription in a larger sample of European hospitals, as compared to the PPS-2006 study.

Methods: Data was collected during two subsequent calendar weeks in May-July 2008 in 50 hospitals in 26 European countries. The study protocol was a simplified version of the 2006 one. An internal web-based application was developed and PDA was used in a subset of hospitals. Antimicrobial prescriptions were recorded using the ATC classification. Demographic data on treated patients, indications, diagnoses, culture pre-therapy and reasons for treatment recorded in notes were collected.

Results: Among the 25,710 admitted patients, 8,126 (31%) received antimicrobials for a total of 11,208 therapies of which 5,601 (69%, 68% in 2006) were monotherapy. Antibiotics represented 90% of the prescriptions (range: 74–96). The most commonly prescribed antibiotics were penicillins with beta-lactamase inhibitor (22%, range: 0–55), cephalosporins (20%, range: 3–60), and fluoroquinolones (13%, range: 0–40). In intensive care wards, glycopeptides represented the third class (7%, range 0–25), followed by the fluoroquinolones. The proportions of parenteral use within the total antibiotic prescriptions, the penicillins and the fluoroquinolones were 74% (64% in 2006), 32% and 6% respectively, however wide variations occurred between hospitals. Infections represented 74% (78% in 2006) of all the indications. Among the curative treatments, 66% (62% in 2006) were for community-acquired infections. Pneumonia and skin and soft tissue infections were the predominating diagnoses representing respectively, 25% and 16%. Surgical prophylaxis represented 72% (68% in 2006) of all prophylactic treatments. The >1 day course for surgical prophylaxis that was already high in 2006 (56%) increased to 65% (range: 57–100 depending of the site) in 2008. The use of single dose pre-operative prophylaxis ranged from 0% to 91% within the hospitals.

Conclusion: The PPS 2008 results, based on a larger sample of hospitals and countries are in accordance with the 2006 PPS data. The survey confirmed the too long duration of surgical prophylaxis and the predominance of the parenteral route. ESAC successfully developed a web-based and PDA tool for surveying antibiotic use and quality assessment in European hospitals, which will be rolled out in 2009 to many European hospitals.

Session Details

Date: 16/05/2009
Time: 00:00-00:00
Session name: 19th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Helsinki, Finland, 16 - 19 May 2009
Presentation type:
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