Interrelation between typhoid fever process and monocytes with expression of C3bR receptor

Abstract number: R2542

Tuychiev J., Aripov S.

Objectives: To reveal interrelation between typhoid fever process (complicated and relapse flow) and monocytes with expression of C3bR receptor.

Methods: 60 patients in 16–67 of age (25 male and 35 female) with typhoid fever, caused chloramphenicol susceptible strain of Salmonella enterica serotype typhi, were tested for determination of C3bR receptor's expression of monocytes with test of rosette formation (Mendes N.F. et al., 1973). There was evaluated the percentage index of rosette formatting monocytes (RFM%) with C3b component of complement. Average rate of this index was 39.0±2.6% in the control group, consisted from 45 healthy people in 17–61 of age (21 male and 24 female).

Results: Among 60 patients relapse of typhoid fever occurred in 12 (20.0%) patients, complications in 7 (11.7%) patients [in 3 (5.0%) case of intestinal bleeding; intestinal perforation, nosebleed, meningoencephalitis and toxic shock in 1 (1.7%) cases]. RFM% index was in low level in 23 (38.3%) patients, in high level in 29 (48.3%) and in the limits of control group indexes in 8 (13.3%) cases. Among 23 patients with low RFM% indexes relapse of typhoid fever was registered in 12 (52.2%) patients, complications occurred in 5 (21.7%) patients. In 6 (26.1%) patients of this group complications and relapses did not registered. In the group of 29 patients with high level of RFM% indexes complications occurred only in 2 (6.9%) patients (intestinal bleeding and toxic shock), vice-versa in majority patients – 27 (93.1%) with high indexes of RFM% there was not any unfavourable outcome. All 8 (100%) patients with normal RFM% indexes unfavourable outcome was not registered as well.

Conclusion: Low indexes of monocyte with C3bR receptor expression in membrane associate with high risk of developing of typhoid fever relapses and complications. High indexes of C3bR expression associate with low risk of complication's developing and absence of relapse's risk in typhoid fever patients. The method of identification of monocytes expressed C3bR receptor can be used in patients with typhoid fever both as a revelation immunodeficiency persons and as a criterion of forecast of disease's flow.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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