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Neonatal bacteraemia: bacteriological profile and antimicrobial susceptibility pattern

Abstract number: R2537

Al-Sweih N., Khan S.

Introduction: Neonatal septicaemia remains a significant cause of morbidity and mortality in the new born. This study was carried out to determine the bacteriological profile, the antimicrobial susceptibility of the blood isolates and the change in the trends over the study period.

Methods and Materials: All blood isolates from cases of neonatal bacteraemia (single isolate per episode) were taken over a period of 5 years (January 2002–December 2006) at the Maternity hospital, Kuwait. Routine identification and susceptibility testing were performed mainly by using VITEK 2 system. E test may be used for some isolates.

Results: There was 1551 episode of bacteraemia during the study period. The most common isolated organism was coagulase-negative Staphylococci (45%). Gram-negative organisms were isolated in 464 (30%) of cases and the most common isolate was Klebsiella pneumoniae (37.1%). Other Gram-negative isolated were Escherichia coli (14.2%), Enterobacter spp. (14%) and Acinetobacter spp. (15.3%). All Gram-positive cocci were susceptible to vancomycin and most Gram-positive cocci other than Staphylococci were susceptible to ampicillin. No meticillin-resistant Staphylococcus aureus were isolated. Most of the Gram-negative were sensitive to amikacin (95.7%), ciprofloxacin (95.3%), tazobactam-piperacillin (95.3) and for meropenem (99.1%) while they were more resistant to cefotaxime (46.9%), ceftazidime (34.9%) and only 10.9% were resistant to gentamicin.

Conclusion: The bacteriological profile of organism causing neonatal bacteraemia is comparable to other reports in literature. Over the study period we observed a trend of increasing resistance to commonly used antibiotics among Gram-negative isolates.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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