Blood culture statistic study in febrile neutropenic haematology patients

Abstract number: R2514

Bronk M., Kochowska-Bronk M., Komarnicka J., Sledzinska A., Samet A.

Objectives: The aim of study was to evaluate the frequency patterns of bacterial pathogens isolated from blood cultures in febrile neutropenic patients hospitalised in haematology unit over the three years period..

Methods: A total number 1322 of blood cultures were examined, using the (automated) Bact/Alert Blood Cultures System. All isolates from positive blood cultures, after classic subculture methods, were characterised at species level by the Vitek system. Antibiotic susceptibility testing was performed using automated Vitek system according to CLSI recommendations. All the investigated patients were neutropenic (WBC < 500) with fever (>38°C) and were under antimicrobial and/or antifungal therapy at the time of blood culture.

Results: Over the three years period (2005–2007) 1322 blood cultures were performed on the basis of the physicians request from 321 patients (with febrile and neutropenic) hospitalised in the haematology ward of our hospital. The pathogens were isolated from 363 blood cultures from 321 patients.

Among the 363 bacterial strains isolated from bloodstream infections 261 were Gram-positive strains (71.90%), 91 Gram-negative strains (25.07%) and 11 yeast (3.03%).

In the group of Gram-positive bacteria were: S. epidermidis 147, E. faecium 50, S. aureus 16, S. hominis 11, S. haemolyticus 9, E. fecalis 9, S. mitis 9, C. jeikeium 5, S. salivarius 2, S. sanguis 2, S. intermedius 2. In the group of Gram-negative strains were: E. coli 24, P. aeruginosa 13, E. cloacae 12, K. pneumonia 12, S. maltophilia 10, A. baumannii 7, A. lwoffii 5, S. marcescens 4, C. freundii 3, S. enteritidis 1.In the group of yeast were: Candida albicans 4, C. krusei 3, C. glabrata 2, C. famata 1, C. parapsilosis 1. In the Enterococcus isolates were 8/59 glycopeptide resistant strains (13.56%) and 2 isolates resistant to linezolid (3.39%). All the Staphylococcus isolates were susceptible to glycopeptide and linezolid. All the Gram-negative rods were susceptible to imipenem and meropenem.

Conclusion: Gram-positive bacteria are common pathogens in neutropenic haematology patients. Glycopeptides (teicoplanin and vancomycin) were effective for the treatment of infections caused by Staphylococcus spp. and E. faecalis. Linezolid is effective in the treatment of infections caused by Gram-positive pathogens including glycopeptide resistant Enterococcus spp. Imipenem and meropenem were effective for the treatment of infections caused by Gram-negative pathogens.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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