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Fungal infections at a Coimbra burns unit: 2003–2007

Abstract number: R2459

Caetano M., Ramos S., Abreu J., Casalta J., Pinheiro S., Diogo C., Cabral L., Cruzeiro C.

Objectives: Analyse the fungal infections, as well as the results of systemic antifungal therapy in Coimbra Burns Unit (Portugal), during the study period.

Methods: The authors retrospectively reviewed data of the patients who developed fungal infections, admitted to the Burns Unit, from January 2003 to November 2007. Epidemiological, microbiological and pharmacological parameters were collected. The data was analysed using the statistical programme SPSS.

Results: During the study period, 856 patients were admitted to the burn unit and 69 patients were enrolled in the study, however, only 41 had complete data for the statistical analysis. The characteristics of the patients admitted were: 62.9% male, mean age of 57.28 (± 87.6) years [11; 96] and mean total burned body surface area (TBSA) of 15.8 (± 18.06) % [1; 100], versus 56.1% male, mean age of 63.54 (± 21.3) years [16; 96] and mean burned TBSA of 28.39 (±16.1) % [5; 60], for the patients enrolled. The mean hospital stay in the Burns Unit was 16.72 days, whereas, 46.34 days for the enrolled patients and the mortality average was 15.2% and 36.6% (40.2%/year), respectively. Eight per cent of the patients developed fungal infections. Candida infection was the most common (82%), being Candida albicans the main isolated specie (56%). The antifungal agent most prescribed was amphotericin B liposomal preparation (44%). In the study population, no statistical significant difference was found when comparing the days of hospital stay required by the patients that used different antifungal treatment.

The mean cost of hospitalisation in Coimbra Burns Unit was 3272 [euro] for the average patient versus 11,915 [euro] for a patient with antifungal therapy.

Conclusions: In the study population, a higher mean age and also a greater mean percentage of TBSA was present in those patients who developed fungal infections. These patients also required more days in the hospital and had a higher mortality rate. Microbiological data should be used frequently to monitor the evolution of the most frequent fungal infections and in order to choose an adequate antifungal drug since these agents contribute to higher costs of treatment.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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