Laboratory diagnosis of Crimean-Congo haemorrhagic fever in Iran in the year 2007

Abstract number: R2425

Chinikar S., Ghiasi S., Goya M., Moradi M., Afzali N., Rahpeyma M., Zeinali M., Bouloy M.

Objectives: Crimean-Congo Haemorrhagic Fever (CCHF) is a viral zoonotic tick-born disease with a mortality rate up to 50% in humans. The CCHF Virus (CCHFV) is from genus Nairovirus and family Bunyaviridae. CCHFV is transmitted to humans by the bite of infected tick and by direct contact with blood or tissues from infected humans and livestock.

Methods: In the year 2007, sera were collected from Iranian CCHF probable cases and sent to the National Reference Lab, Pasteur Institute of Iran. These sera were analysed with Immunological (specific ELISA) and molecular (RT-PCR) assays.

Results: Among 128 probable human cases, 53 were confirmed cases. Between confirmed ones, 42 were IgM positive (37 among them were also RT-PCR positive) and 11 cases were only RT-PCR positive. Just one case led to death during the year 2007(up to 14 November), comparing with the year 2001 in which 11 death between 66 confirmed cases were observed.

Conclusion: CCHF is in the most important viral haemorrhagic fevers in Iran. In this year, 16 out of 30 provinces of Iran have been affected by CCHF. Sistan-Balouchestan in the southeast of Iran, because of being near the border of endemic countries (such as Pakistan, Afghanistan), has the highest rate of CCHF. In this study, it was demonstrated that CCHF was seen much more in the age range of 21–40 and is more common in professions related to livestock such as butchers, slaughterers, farmers, etc. Therefore, it seems, informing the groups of high risk professions has been efficient. Fortunately, with a precise surveillance and laboratory detection, the mortality rate in the year 2007(till 14 November) is decreased up to 2% in contrast to 17% in the year 2001.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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