Correlation of antibodies to antigens of Epstain-Barr virus with systemic lupus

Abstract number: R2386

Seremet M., Hukic M., Sisirak M., Mahmutovic-Vranic S.

Objectives: We have examined a correlation of Epstein-Barr virus (EBV) infection with Systemic lupus (SLE). We determined antibodies on EBV specific antigens and heterophilic antibodies in SLE patients and control group.

Methods: The SLE group consisted of 50 patients treated at the Clinic for Rheumatism or at the Rheumatologic Counseling Office of the same Clinic. Mean age of the group was 48 years. The female-male ratio was 47/3. The control group consisted of 21 patients with degenerative arthritis and 29 clinicaly healthy individuals, all of the similar age and gender structure as the SLE group. Each serum samle was tested by Elisa for: Enzygnost anti-EBV/IgG, Enzygnost anti-EBV/IgM, anti-VCA/IgG, anti-VCA/IgM, anti-EA-D/IgG, anti-EBNA-1/igG and heterophilic antibodies.

Results: Anti-EBV/IgG antibodies were positive in 50 (100%) SLE patients and 39 (78%) controls. SLE and control groups were negative for EBV/IgM antibodies. Anti-VCA/IgG and anti-EBNA-1/IgG antibodies were positive in 50 (100%) SLE patients and 39 (78%) controls. SLE and control groups were negative for anti VCA/IgM antibodies. Anti-EA-D/IgG antibodies were positive in 35 (70%) SLE patients and 8 (16%) controls. Heterophilic antibodies were positive only in two SLE patients.

Conclusion: There was no significant difference in frequency of anti-EBV antibodies in two groups (p = 0.585). However, the percentage of high antibodies concentrations in serum was significantly higher in SLE patients than in control group (p = 0.0001). The frequency of anti-VCA and anti-EBNA-1 antibodies was similar in both groups, while the frequency af anti-EA-D antibodies was significantly higher in SLE.

EBV infection is closely related to SLE, whether as a triggers or as precursors of EBV infection.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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