In vitro activities of tigecycline against Aeromonas, Vibrio, and Salmonella species, Taiwan

Abstract number: R2321

Huang Y-T., Liao C-H., Liu C-Y., Hsueh P-R.

Background:Aeromonas, Vibrio, and Salmonella species are endemic pathogens associated with a variety of clinical infections in Taiwan. There are few reports regarding in vitro activities of tigecycline against these pathogens.

Methods: A total of isolates of Aeromonas, Vibrio, and Salmonella species were tested. These organisms were isolated from various clinical specimens (blood, stool, and pus).

MICs of tigecycline were determined by using the broth dilution method (CLSI). The results were interpreted by the MIC criteria provided by U.S. FDA tigecycline susceptibility breakpoints listed for Enterobacteriaceae (S, leqslant R: less-than-or-eq, slant2 mg/L; I, 4 mg/L; R, geqslant R: gt-or-equal, slanted8 mg/L)

Results: All 81 Aeromonas hydrophila, 57 A. sobria, 198 non-typhoid salmonella, and 92 Vibrio isolates were susceptible to tigecycline. One out of 63 A. caviae isolates revealed intermediate to tigecycline.

Conclusions: Nearly all isolates of Aeromonas, Vibrio, and Salmonella species tested were susceptible to tigecycline. Further in vivo studies should be conducted to confirm the clinical efficacy of tigecycline for the treatment of infections due to these organisms.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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