Urinary tract infection pathogens and their susceptibility to antimicrobials at a university hospital, Setif, Algeria: a 7-year study (20002006)
Abstract number: R2316
Sahli F., Radji N., Touabti A.
Objectives: To determine the most frequent pathogens causing urinary tract infection isolated at the microbiology laboratory of the Setif university hospital in Algeria during 7 years and we report their susceptibility (S) rates to antimicrobials.
Methods: 3227 isolates were collected from urine specimens during 7 years (20062007). Strains were identified by standards methods. S to antimicrobial agents was tested according to the CLSI guidelines as well as the detection of the extended spectrum betalactamase phenotype (ESBL).
Results: The most frequent pathogens were E. coli (59.4%), Klebsiella (12.9%), Proteus (8%), Pseudomonas aeruginosa (4.89%), Enterococcus (3%) and Staphylococcus aureus (2.23%). For the commonly isolated Enterobacteriaceae, antimicrobials S rates were: cefotaxim (89.4%), imipenem (100%), ciprofloxacin (86.6%) and triméthoprim/sulfamethoxazole (sxt) (52.2%). ESBL phenotype rates were 6.6% for E. coli, 8% for Proteus and 30% for Klebsiella. The S rates for Pseudomonas aeruginosa were as follow: piperacillin (57.9%), ceftazidime (64.9%), imipenem (94.8%), ciprofloxacin (69.7%) and colistin (100%). Enterococcus was susceptible to ampicillin in 62.2%, tetracycline in 20.6% and vancomycin in 100%. For Staphylococcus aureus, oxacillin was active at 71.8%, ofloxacin 82.2%, sxt 85.5% and vancomycin 100%.
Conclusion: Enterobacteriaceae and specially E. coli remained the most frequent urinary tract infection pathogens. The most actives antimicrobials agents were imipenem and third generation cephalosporins (3GC) although emerging BLSE phenotype had reduced the 3GC activity particularly on Klebsiella isolates. Fluoroquinolones were still actives but their S rates decrease progressively. Using adequate antimicrobial therapy with broad spectrum agents will not solve the multidrugresistant bacteria problem if strict measures aren't applied to avoid such isolates spread.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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