Sensitivity profile to some new antibiotics of most frequently encountered bacterial species in infections in a hospital in Romania – Comparison 2003 vs. 2006

Abstract number: R2294

Ciubotariu D., Lunca C., Frasin V., Antonesi I.

Objective: To evaluate the evolution of bacterial resistance to some highly active, new antibiotics of the most frequently encountered bacterial species in the Emergency University Hospital, Iasi, Romania, in 2006 compared to 2003.

Methods: Retrospective evaluation of charts and records of hospital's Microbiology Laboratory (from January 1 to December 31, 2003 and from January 1 to December 31, 2006). Bacterial sensitivity to antibiotics was performed using disk diffusion method. For each antibiotic, results were expressed as: sensitive, intermediate or resistant, according to CLSI Guidelines. Comparison between resistance profile in 2003 and 2006 was performed using chi-squared test.

Results: In the investigated period, there were 1917 biological samples from hospitalised patients sent for identification and antibiogram. The bacterial species was identified in 76.00% of cases (1457 samples). The three most frequently encountered identified species were: Staphylococcus aureus (512 samples, 35.14% of identified species, 26.71% of total samples), Acinetobacter baumannii (178 samples, 12.22% of identified species, 9.29% of total samples) and Pseudomonas aeruginosa (162 samples, 11.12% of identified species, 8.45% of total samples). Comparative evaluation of resistance profile for Staphylococcus aureus revealed un-modified sensitivity to vancomycin (0 in 2003 vs. 2.21% in 2006) and linezolid (2.49% in 2003 vs. 3.32% in 2006) and increasing sensitivity to teicoplanin (from 36.1% in 2003 to 49.08% in 2006, p < 0.01) and cefpirom (from 26.14% in 2003 to 33.95% in 2006, p < 0.05). Percentage of meticillin-resistant strains increased from 51.03% in 2003 to 70.18% in 2006 (p < 0.01). Acinetobacter baumannii developed significant resistance to imipenem (from 18.29% in 2003 to 31.76% in 2006, p < 0.01). In case of Pseudomonas aeruginosa, we also noticed increasing resistance to imipenem (from 25% in 2003 to 33.78% in 2006, p < 0.05), while sensitivity to cefpirom remained un-modified (45.45% in 2003 and 45.94% in 2006).

Conclusions:Staphylococcus aureus isolated strains keep satisfactory sensitivity to vancomycine and linezolid (about 97%). Surprisingly, Staphylococcus aureus sensitivity to teicoplanin and cefpirom increased. Increasing resistance to imipenem of Acinetobacter baumannii and Pseudomonas aeruginosa, as well as increasing percentage of MRSA strains are to be considered. Rational use of carbapenems in infections should be implemented.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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