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Prevalence of gastroenteritis caused by rotavirus and adenovirus in a paediatric population in Athens, Greece

Abstract number: P2215

Paleologou N., Lykou F., Tsialta P., Zouni P., Dimitraka V., Synodinou E., Lebessi E.

Objective: Acute gastroenteritis (AGE) is a major source of morbidity in early childhood. Enteropathogenic viruses are regarded as particularly relevant causative agents. Our study was performed to estimate the prevalence of gastroenteritis caused by group A rotavirus and enteric adenovirus among young children during a two-year period (2006–2007) in the area of Athens.

Methods: We reviewed retrospectively the laboratory cards of children under five years old, who were tested for group A rotavirus and enteric adenovirus, the major enteric viral pathogens. The detection of the viruses was carried out according to standard methods using a commercial immunochromatography assay kit.

Results: A total of 1 228 patients, younger than 5 years of age seeking medical care for acute diarrhoea in our hospital, were enrolled in the study. Diarrhoea, vomiting and fever were the main clinical manifestations. All stool samples from inpatients were collected within three days of hospitalisation. They were all tested for rotavirus and adenovirus. Group A rotavirus was the most frequently detected (176/1 228, 14.33%), followed by enteric adenovirus (30/1 228, 2.4%). Dual infections were found in 2.66% of the positive samples. Group A rotavirus gastroenteritis occurred in 87 boys and 89 girls and adenovirus gastronteritis occurred in 12 boys and 18 girls (male/female ratio 1:2). The median ages were similar (10 months for rotavirus and 11 months for adenovirus, range 30d-5years). The majority of patients were less than 3 years old; 82% and 76% for rotavirus and adenovirus infection, respectively. Rotavirus infection was most common in the winter through early spring, peaked between January and May. Enteric adenovirus gastroenteritis occurred year-round. Hospital outbreak was not recorded. All cases were classified as community-acquired. The results from 2007 will be completed at the end of the year.

Conclusions: Rotavirus is a significant viral agent among children, especially those younger than three years. The overall incidence of viral gastroenteritis could have been higher than currently observed, if the included patients had been tested for astrovirus and calicivirus.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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