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Experimental models of upper urinary tract infections caused by sexually transmitted diseases isolated or in conjunction with non-specific agents

Abstract number: P1930

Loran O., Sinyakova L., Kosova I.

Objectives: Experimental models of low urinary tract infections caused by non-specific agents are known. There are no reports which show the role of sexually transmitted diseases (STD) in ethiology of upper urinary tract infections. This study was performed to prove the role of STD in ethiology of urinary tract infections.

Methods: Experimental model of acute pyelonephritis was created on 13 rabbits by ligation of right ureter near urinary bladder with further injecting in ureter cultures of Ureaplasma urealyticum, Chlamydia trachomatis, E. coli, isolated and in different combinations. The final testing was performed on 3 and 7 days.

Results: Inflammation process in upper urinary tract of experimental animals caused by Ureaplasma urealyticum has the following pathologic characteristics: the presenñe of ballooning degeneration of pelvic epithelium developed in early stages, the absence of intensive granulocytic reaction. Ureaplasma urealyticum realizes its pathogenic properties through membrane destruction with further formation of cell vacuoles and then colliquative necrosis.

The action of Ureaplasma urealyticum in combination with non-specific agents (E. coli) leads to intensive cell permeability and to early and more intensive developing pyoinflammation reaction. The action of Chlamydia trachomatis infection leads to formation of multiple calcified focuses whether its combination with E. coli – to primary chronical process formation.

Conclusion: Inflammatory process of upper urinary tract of experimental animals caused by specific agents (Ureaplasma urealyticum and Chlamydia trachomatis) in case of isolating injection leads to primary chronical process and in combination with non-specific agents to early and more intensive pyoinflammation reaction in the animal's kidney.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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