Comparison of quinupristin-dalfopristin and vancomycin in the treatment of experimental endocarditis due to ampicillin- and gentamicin-resistant E. faecium
Abstract number: P1919
Perivolioti E., Vryonis E., Fanourgiakis P., Platsouka E., Samarkos M., Katsimpoulas M., Balafas E., Kostomitsopoulos N., Karagianakos P., Skoutelis A., Paniara O.
Objectives: Drug resistance among enterococci necessitates the search for new treatment options.
In this study we tested the efficacy of vancomycin and quinupristin-dalfopristin in a rabbit model of experimental endocarditis due to an ampicillin (AMP) & gentamicin (GEN) resistant and glycopeptides susceptible clinical isolate of Enterococcus faecium.
Methods: We used the left side experimental endocarditis model. We inoculated animals with E. faecium one day after the insertion and fixation of a polyethylene catheter into the left ventricle. Thirty-six hours later they were randomly assigned to a control group (C), and groups receiving quinupristin-dalfopristin 30 mg/kg/q8 h IM x 5 days (QD) or vancomycin 50 mg/kg/q12 h IM x 5 days (V). All animals were sacrificed at the end of treatment. Therapy response was determined by blood cultures and quantitative (log10 cfu/gr of tissue) cultures of aortic valve vegetations, liver, spleen, kidney and brain.
Results: The results obtained of the different therapeutics groups are expressed in the Table.
Conclusions: Although both regiments reduce significantly the bacterial count per gram of vegetations, treatment with V was found to be more potent than QD. Also animals treated with V had lower bacterial counts per gram of liver, brain and spleen tissue.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
|Back to top|