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Comparison of quinupristin-dalfopristin and vancomycin in the treatment of experimental endocarditis due to ampicillin- and gentamicin-resistant E. faecium

Abstract number: P1919

Perivolioti E., Vryonis E., Fanourgiakis P., Platsouka E., Samarkos M., Katsimpoulas M., Balafas E., Kostomitsopoulos N., Karagianakos P., Skoutelis A., Paniara O.

Objectives: Drug resistance among enterococci necessitates the search for new treatment options.

In this study we tested the efficacy of vancomycin and quinupristin-dalfopristin in a rabbit model of experimental endocarditis due to an ampicillin (AMP) & gentamicin (GEN) resistant and glycopeptides susceptible clinical isolate of Enterococcus faecium.

Methods: We used the left side experimental endocarditis model. We inoculated animals with E. faecium one day after the insertion and fixation of a polyethylene catheter into the left ventricle. Thirty-six hours later they were randomly assigned to a control group (C), and groups receiving quinupristin-dalfopristin 30 mg/kg/q8 h IM x 5 days (QD) or vancomycin 50 mg/kg/q12 h IM x 5 days (V). All animals were sacrificed at the end of treatment. Therapy response was determined by blood cultures and quantitative (log10 cfu/gr of tissue) cultures of aortic valve vegetations, liver, spleen, kidney and brain.

Results: The results obtained of the different therapeutics groups are expressed in the Table.

Conclusions: Although both regiments reduce significantly the bacterial count per gram of vegetations, treatment with V was found to be more potent than QD. Also animals treated with V had lower bacterial counts per gram of liver, brain and spleen tissue.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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