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Use of a clinical laboratory database to estimate the incidence of Toxoplasma gondii infection among women of childbearing age: a longitudinal retrospective study

Abstract number: P1876

Martínez-Serrano M., Bartolomé-Álvarez J., Moreno-Parrado L., Lorente-Ortuño S., Crespo-Sánchez M.

Objective: To know the incidence of Toxoplasma gondii infection in women of reproductive age in Albacete, Spain.

Methods: We designed a longitudinal retrospective study of seronegative childbearing-aged women. This study was conducted in an area where prenatal serological screening for T. gondii infection is routinely performed. Serological testing within this area is centralised in a unique laboratory. We used the database of this central laboratory as the only source of information for this study. We included in the study all the women 14–44 years old who fulfilled all three criteria that follow: 1) they had at least two determinations of T. gondii IgG performed between Feb-2001 and Mar-2007, 2) the first determination of T. gondii IgG was negative, and 3) the last determination was separated from the first one by an interval of time of at least one year. The patients were classified in: 1) not infected, if all the determinations of T. gondii IgG were negative, 2) confirmed seroconversions, if the patient had a) at least two determinations of T. gondii IgG with negative result followed of at least two determinations with positive result or b) a determination of T. gondii IgG with negative result followed of at least two determinations with positive results for both T. gondii IgG and IgM, and 3) possible seroconversions, if the patient had at least one determination of T. gondii IgG with negative result followed of at least one determination with positive result but was not fulfilling the criteria of confirmed seroconversion. For every patient it was calculated a time at risk of acquiring the infection, which was the interval of time between the first one and the last determination of antibodies.

Results: We studied 2,416 women with a mean age of 29 years (SD = 5). The median time at risk was 35 months (interquartile range = 23–46), and the total sum of times at risk was 7,121 women-year. There were 5 confirmed and 3 possible seroconversions. None of these seroconversions was detected during a pregnancy. There were 0.7 confirmed and 0.4 possible seroconversions per 1,000 women-year. So, the true incidence was between 0.7 and 1.1 seroconversions per 1,000 women-year (that is, 0.5–0.8 per 1,000 women-9 months).

Conclusion: The incidence of T. gondii infection among women of childbearing age was low. Analysis of the laboratory database is a useful approach to monitor the incidence of infection in areas where prenatal screening for toxoplasmosis is performed.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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