Brucellosis: an evaluation of 100 cases in Central Anatolia

Abstract number: P1857

Naz H., Aykin N., Cevik F., Bal C.

Objectives: Brucellosis is a frequently encountered zoonosis in various regions of the world, including the Mediterranian region. It is endemic in some regions of our country, especially in the central Anatolian region. In our study we investigated restrospectively the brucellosis cases, in our hospital, our aim was to share the clinic, laboratory and therapy findings and to investigate their relationship with relapse rates.

Methods: A total of 100 patients diagnosed as brucellosis in our clinic between 2001 and 2006 were reviewed. The diagnosis was made by clinical symptoms together with laboratory results; titer >1:160 in the standard tube agglutination test (STA) and/or isolation of brucella species from blood and other bodily fluids or tissues. The Chi-squared test, Student's, Mann-Whitney U test, Kolmogorov-Smirnov Test were used for statistically analysis.

Results: In the 6 year study time 100 cases of brucellosis were established. 66 were male, and 34 were female. Among the 100 cases diagnosed as brucellosis, a total of 70 complications were found in 54 patients. The most common complications were found in osteoarticular, gastrointestinal and genitourinary systems as showed in the table 1. During follow up after treatment, relaps were seen in 28 cases. When the patients' demographic, clinical, and laboratory findings were evaluated, in relation to relapse, family history of brucellosis, living in rural areas and the presence of complications were related to higher relapse rates. Comparison of 100 patients with brucellosis with or without relapse are given in table 2. The most frequently used antibiotic combinations were; 77 doxycycline+rifampin, 10 doxycycline+streptomycin, 10 rifampin+ciprofloxacin, 1 doxycycline+rifampin+ciprofloxacin, 1 doxycycline+gentamycin, 1 doxycycline+streptomycin+ciprofloxacin. There was no significant statistical difference in the relapse rates according to the antibiotic used (p = 0.697). There was no mortalities.

Conclusion: In our study, we found that relapse was related to positive family history, living in rural areas, and the presence of complications. Brucellosis, still preserves its importance in our country, as it is endemic, shows a great variety of symptoms, can affect different systems, and there is still therapy handicaps and relapses are seen frequently. The efforts shown for the diagnosis and therapy should also be shown for protection and control strategies.

Table 1. Comparison of 100 patients with brucellosis with or without relapse

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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