Time-to-positivity of blood cultures in patients with Klebsiella spp. bacteraemia

Abstract number: P1829

Peralta G., Roiz M.P., De Benito I., Teira R., Ceballos B., Alonso S., Garrido J.C., Mateos F., Sanchez M.B., Padron E.

Background: time to positivity of blood cultures (TTP) is considered a surrogate marker of blood bacterial concentration. We evaluate the relationship between the TTP with clinical parameters, in patients with Klebsiella spp. bloodstream infections.

Methods: retrospective study of cases of Klebsiella spp. monomicrobial bloodstream infections from January 1997 to June 2007 in our institution. The association of more than 20 variables, including epidemiological and clinical aspects of Klebsiella spp. cases, with TTP was evaluated. When multiple cultures were positive only the shortest TTP was selected for the analysis. Chi-square test or the Fisher test were used for categorical variables and t-test for continuous variables.

Results: during the study period we identified 78 cases of Klebsiella spp. monomicrobial bacteraemia, with a mortality of 11.5%. Median (interquartile range) TTP was: 12.5 h (10.5–15.1). In one case TTP was unknown. Significant correlation among TTP and the number of positive blood cultures was found (Spearman's coefficient = -0.44, p < 0.001). Association of TTP with several clinical parameters is reflected the table. Mortality in patients with TTP <9 h was 33.3% (2/6), in those with TTP between 9–10 h 14.3% (1/7), and in patients with TTP >10 h mortality was 8.4% (5/64) (chi for trend, p = 0.06).

Conclusions: in patients with Klebsiella spp. bacteraemia, TTP is associated with the severity of the infection and with the outcome.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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