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Lower saliva flow rates are associated with oral affection of Candida sp. after radiation therapy

Abstract number: P1804

Karbach J., Herzog M., Ponto K., Al-Nawas B.

Objectives: Xerostomia is one of the late side effects of radiation therapy in patients with head and neck cancer associated with great impairment of quality of life. Radiation therapy can also predispose to oral candidal colonisation of the oral mucosa in the immuncompromised patients. This study was focused on correlation between the total unstimulated saliva flow rate and the fungal colonisation of the oral cavity.

Methods: In 30 patients who had radiation therapy the unstimulated saliva flow rate was analysed during five minutes. According to the measured rates the results were divided into pronounced xerostomia (unstimulated whole saliva flow rate = 0.0 ml/min), xerostomia (unstimulated whole saliva flow rate leqslant R: less-than-or-eq, slant0.1 ml/min) and hyposalivation (unstimulated whole saliva flow rate >0.1–<0.25 ml/min). After determination of the saliva flow rate 2 ml sodium chloride were used to rinse out the mouth for 20 seconds. Candida colonisation was defined using sabouraud agar and identified using API Candida (biomerieux) in the mouth rinsing water of patients.

Results: Pronounced Xerostomia was detected in 17 patients (median = 106 cfu; range 0–107 cfu), xerostomia in 11 patients (median = 105 cfu; range 0–106 cfu) and hyposalivation in 5 patients (median = 0 cfu; range 0–106). Spearman's correlation coefficient was -0.331 (p = 0.06). In our collective there was no patient having a normal saliva flow rate. 11 Candida-species were identified as Candida albicans, 5 as Candida famata, 4 as Candida glabrata, 1 as Candida tropicalis, 1 as Candida dubliniensis and 3 as Saccharomyces cerevisiae. In 8 patients no Candida-species were detected.

Conclusion: Lower saliva flow rates correlate with a higher risk for Candida affection in patients after radiation therapy.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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