Survey of candidaemia in a tertiary care hospital in Greece.
Abstract number: P1792
Skiada A., Masgala K., Chatzihannas L., Anyfantis I., Travlos A., Stefanou I., Mitroussia-Ziouva A., Daikos G.L., Petrikkos G.
Objectives:Candida is an important pathogen in the hospital setting. The aim of this study was to analyse the morbidity and mortality related to candidaemia in our hospital, as well as to record the isolated species of the fungus.
Methods: Prospective epidemiological study, in a tertiary care hospital. The demographic characteristics of all the patients who developed candidaemia were recorded, as well as the underlying diseases, possible predisposing factors, such as presence of central venous catheters, diabetes mellitus, renal failure, etc. The species of Candida isolated from blood cultures was identified with Chromagar and API 32C and sensitivity testing was done with the microdilution method.
Results: The study started in January 2006 and is in progress. We report the results of the first 18 months. During this period 49 episodes of candidaemia were recorded in 49 patients. Their mean age was 60 years (range 20 to 90) and 65% of them were male. Twenty-eight were from the surgical, 2 from the urology and 9 from the medical departments and 10 from the ICU. One patient (2%) was neutropenic, 35 (71%) had central venous lines and were receiving parenteral nutrition.
The isolated species were C. albicans (17), C. parapsilosis (19), C. glabrata (8), C. sake (1), C. lusitaniae (1), Pichia ohmeri (1) and C. tropicalis (2). The C. glabrata strains were all, except one, resistant to fluconazole, two were intermediately and one fully resistant to voriconazole, while the C. parapsilosis, C. lusitaniae, as well as the C. albicans strains were susceptible to all antifungals tested, with the exception of two isolates of C. parapsilosis resistant to caspofungin and one strain of C. albicans resistant to fluconazole, itraconazole and voriconazole. In addition, there were three strains of C. parapsilosis with dose-dependent resistance to fluconazole and two to itraconazole. The isolate of Pichia ohmeri was resistant to caspofungin and had dose-dependent resistance to fluconazole and itraconazole. The crude mortality of the patients who developed candidaemia was 42%.
Conclusions: Non-albicansCandida species are more common than C. albicans in our hospital and C. parapsilosis is the prevailing species. The greatest number of cases is recorded in surgical patients and not in patients with neutropenia or other medical underlying diseases. Total parenteral nutrition is very common in patients who develop candidaemia.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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