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Incidence of candidaemia: 5-year results from emerging infections in patients from the intensive care unit of a tertiary hospital

Abstract number: P1788

Cortizo-Vidal S., Santiago I., Villamil-Cajoto I., Rodriguez-Otero L., Martinez-Lamas L., Aguilera-Guirao A., García-Riestra C., García-Zaabarte Á.

Introduction: The incidence of severe Candida bloodstream infections (BSI) is rapidly increasing since the 90`s and it is becoming a major cause of morbidity and mortality in intensive care unit patients. Candida species are now the fourth most common cause of hospital-acquired bloodstream infections. Although the incidence of candidaemia among previously hospitalised patients increased, recent reports suggest that the incidence has stabilised.

Objectives: The purpose of this study was to know the incidence and the tendency of candidaemia during 5 years in an Intensive Care Unit (ICU) from a tertiary hospital.

Methods: A case of candidaemia was defined as the incident isolation of Candida spp. from a blood culture. Candidaemia occurring >30 days after the incident isolation was defined as a new case. To calculate incidence rates, the numbers of admissions and patient-days were collected. Incidence rates were calculated as the number of candidaemias per 1,000 admissions. To compare the tendency of annuals incidences of candidaemias Chi-square test was performed.

Results: We collected a total of 77 consecutive episodes of Candida BSI in adults from ICU. Candida albicans was the most prevalent isolated species (n = 35); the remaining 42 strains were Candida parapsilosis (n = 29); Candida glabrata (n = 4), Candida tropicalis (n = 2); Candida krusei (n = 2); Candida guilliermondii (n = 1) and other Candida spp. (n = 4). The incidence of BSI of Candida albicans rate per 1000 admissions and by year were 2.39, 2.71, 2.87, 2.62 and 3.59; and other Candida non-albicans 2.39, 4.51, 3.28, 3.37 and 3.59. The overall incidence of BSI of Candida rate per 1000 admissions was 7.07, (4.78, 7.22, 6.16, 5.99; 7.18). No significative diferences were found among the annual incidence rates of candidaemia in ICU patients: p = 0.8344 (whole candidaemias); p = 0.9453 (Candida albicans) and p = 0.835 (non-albicans Candida).

Conclusions: Although the study period was reduced, the results do not reveal significative changes in the incidence rates of all candidaemia episodes caused by Candida albicans and non-albicans Candida.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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