Impact of PCV7 on invasive pneumococcal disease in Scotland
Abstract number: P1754
Wilson J., Hill R., Eastaway A.
Objectives: In September 2006, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the Scottish Routine Childhood Immunisation Programme with a catch-up campaign to two years of age. There is a concern that there will be an emergence of serotypes not contained in the 7-valent vaccine.
This study evaluated the impact of the 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease (IPD) in Scotland.
Methods: Health Protection Scotland has routinely collected data on IPD as part of the European Antimicrobial Resistance Surveillance System (EARSS) since 2003.
Data collected between October 2004 and September 2007 inclusive were analysed for this study. Serotype distribution and antimicrobial resistance was investigated for the following age groups:
Results: The total number of cases of IPD in Scotland has decreased since the introduction of the PCV7 into the Scottish Routine Childhood Immunisation Programme.
The number of cases in the under two year old population has statistically significantly reduced.
A reduction in the number of cases can also be seen in the over 65 year population.
There has been an increase in some serotypes not covered by the vaccine. There were a significant number of emergent cases of serotype 35B in the under two year old population and a significant increase in the numbers of serotype 7F was observed in the sixty five and over population.
Table 1 shows that susceptibility of Streptococcus pneumoniae to penicillin, erthromycin and ciprofloxacin has increased since the introduction of PCV7.
Table 1 Antimicrobial susceptibility of Streptococcus pneumoniae
Conclusion: The introduction of PCV7 into the routine childhood vaccination schedule in Scotland has resulted in a decrease of the incidence of vaccine-serotype IPD, and consequently a fall in the overall incidence of IPD. A decline in IPD incidence in all age groups, including those not targeted in the vaccination programme has also been observed. This suggests a strong herd community. There has been an increase in susceptibility to penicillin, erythromycin and ciprofloxacin. There has however been an increase in the numbers of serotypes not covered by the vaccine which highlights the fact that continued surveillance of IPD is essential.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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