Global trends of penicillin resistance rates in Streptococcus pneumoniae, 2004–2007

Abstract number: P1750

Badal R., Bouchillon S., Johnson B., Hackel M., Johnson J., Hoban D., Dowzicky M.

Objectives: The percentage rates of penicillin-resistant (PenR) S. pneumoniae (SPN) vary by country and region. The purpose of this analysis was to determine changes in regional variations of PenR and PenNS strains of SPN, and the current activity of tigecycline (TIG), amoxicillin-clavulanic acid (AC), ceftriaxone (CFX), levofloxacin (LEV), linezolid (LNZ), and vancomycin (VAN) against pen-resistant isolates.

Methods: 5,010 clinically relevant isolates of SPN were collected from patients in 387 hospitals worldwide from 2004 to 2007. MIC's to all agents tested were determined by broth microdilution and interpreted following CLSI guidelines.

Results: Number of SPN and the percentage non-susceptible to penicillin from 2004–2007 are summarised in the table.

% of PenR SPN susceptible to AC ranged from 34–100; CFX from 33–100. 100% of PenR SPN were susceptible to TIG, LEV, LNZ, and VAN.

Conclusions: Rates of PenNS for SPN range from 29% in Europe to 59% in South Africa. Magnitude of changes from 2004 to 2007 varied by region, being fairly constant in Europe, Middle East, and North America, but showing swings ranging from 10–31% (Latin America and Asia/Pacific Rim, respectively). Generally speaking, PenNS rates were essentially constant from 2006–2007; however, the advent of new higher CLSI breakpoints for intravenous penicillin for non-meningitis SPN in 2008 will lead to significant declines in reported PenNS rates in countries using CLSI standards. Utility of AC and CFX vs. PenR SPN varies widely by region, and local susceptibility patterns must be taken into account when selecting therapy.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Location: Barcelona, Spain
Presentation type:
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