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Serotyping and antimicrobial resistance of group B Streptococcus in Korea

Abstract number: P1742

Chae J.D., Ki M., Seo Y.S., Oh K.Y., Shin J-H., Song Y.R., Kim J.M., Kim M.Y., Yang J-Y., Bae S.Y., Yoon H.R., Foxman B.

Purpose: Because of the prevalence of Group B Streptococcus (Streptococcus agalactiae, GBS) among pregnant women and disease burdens in neonates and adults are increasing in Korea; we carried out this molecular epidemiologic study on GBS to estimate the serotype distribution and antimicrobial resistance among colonising and invasive isolates.

Materials and Methods: Colonising isolates (199) were collected by GBS screening in pregnant women (35–37 weeks) between Nov. 2004 and Mar. 2007 in four hospitals of Seoul and Daejeon. Invasive isolates (243) came from patients of clinics or hospitals in whole country between Feb. 2006 and Mar. 2007. To confirm serotype of GBS, co-agglutination assay (serotyping kit) and microarray methods were used. To test antimicrobial resistance, disc diffusion method for colonising isolates and MIC for invasive isolates were used.

Results: Serotype III was predominant and V was the next frequent in colonising isolates, but serotype V was predominant and III was the next in invasive isolates. Antimicrobial resistances for colonising and invasive isolates were high; resistance to erythromycin (27.9%, 35.3%, respectively) and resistance to clindamycin (46.3%, 48.7%, respectively). We also confirmed the resistance to cefazolin and cefuroxime at first in Korea. Antimicrobial resistance was high in serotype V, VII and VIII, and especially, resistance to clindamycin rather than erythromycin was very high in serotype III. When the isolates showed resistance to erythromycin, they also showed resistance to clindamycin except two isolates. However, when the isolates had resistance to clindamycin, 31.7% of them (almost of all was serotype III) were susceptible to erythromycin, which were very different characteristics of Korean GBS isolates.

Conclusion: Serotypes of Korean GBS isolates were moved to virulent serotype V, VII, and VIII and antimicrobial resistance to erythromycin and clindamycin were still increasing: further research and control on GBS were very important in Korea.

Session Details

Date: 19/04/2008
Time: 00:00-00:00
Session name: 18th European Congress of Clinical Microbiology and Infectious Diseases
Subject:
Location: Barcelona, Spain
Presentation type:
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