Carriage of group B streptococcus in pregnant women from Tehran, Iran
Abstract number: P1716
Soltan Dallal M.M., Bakhtiari R., Zaeimi Yazdi J., Fallah J., Pourmand M.R., Bagherzadeh Yazdchi S., Hajikhani S., Chehri Chamchamani B.
Objectives: Group B streptococcus (GBS) is the most common cause of life-threatening infection in neonates but is preventable if the mother is diagnosed before and treated at delivery. The objective of this study was to determine the colonisation rate of GBS in Iranian pregnant women.
Methods: Vaginal and anal swabs were obtained from 125 pregnant women at 3537 weeks' gestation. Two anal and vaginal swabs were taken from each patient. One swab was inoculated to Todd-Hewitt broth supplemented with antibiotic. The other swab was used for a PCR assay, which uses specific primers for cfb gene sequence of GBS DNA.
Results: Out of 125 pregnant women, 12(9.6%) were GBS positive by PCR assay while culture identified 10(8%) women as carriage of Group B streptococcus. Using culture as the gold standard, the sensitivity of PCR assay was 100% and specificity was 98%. The positive predictive value (PPV) and negative predictive value (NPV) for PCR assay were 98% and 100%, respectively.
Conclusion: Group B streptococcus colonisation rate among Iranian pregnant women is relatively high (9.6%). The PCR method seems rapid, specific and highly sensitive assay to detect GBS in anal and vaginal samples taken from pregnant women. The results of this study, recommend screening of pregnant women at 3537 weeks' gestation for GBS to reduce neonatal morbidity and mortality caused by this bacterium.
|Session name:||18th European Congress of Clinical Microbiology and Infectious Diseases|
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